Microregulation of Plaque Neovascularization

Microregulation of plaque neovascularization.

Angiogenesis, the formation of new blood vessels from preexisting ones, is an important phenomenon in various physiological processes, such as embryonic development and pathological conditions, including acute and chronic inflammatory processes, such as wound healing, rheumatoid arthritis, diabetic retinopathy, and tumor progression.1 Plaque neovascularization, first described by Koester more t...

Visualization of Plaque Neovascularization by OCT

Plaque neovascularization and antiangiogenic therapy for atherosclerosis.

The concept that neovascularization of the vessel wall may play a fundamental role in the pathophysiology of atherosclerosis was proposed more than a century ago. In recent years, supportive experimental evidence for this hypothesis (such as the finding that neointimal microvessels may increase delivery of cellular and soluble lesion components to the vessel wall) has been underscored by clinic...

Detection of carotid plaque neovascularization with Superb Micro-Vascular Imaging

Quantification of plaque neovascularization using contrast ultrasound: a histologic validation.

AIMS The density of vasa vasorum within atherosclerotic plaque correlates with histologic features of plaque vulnerability in post-mortem studies. Imaging methods to non-invasively detect vasa vasorum are limited. We hypothesized that contrast ultrasound (CUS) can quantify vasa vasorum during atherosclerosis progression. METHODS AND RESULTS New Zealand white rabbits received a high-fat diet f...